Comparing analysis methods in assessing dynamic dual bolus cardiac magnetic resonance perfusion flow
نویسندگان
چکیده
Background We compare eight reported methods (1-8) for the analysis of cardiac perfusion flow in 3 Tesla MRI on a porcine model. Therefore, an anaesthetized healthy minipig was repeatedly scanned (x5) with a 14 day interval with Turbo FLASH at 3T. The data obtained from the images consists of the temporal course of the arterial input function (AIF) and of the tissue response function (TRF). We compared 8 analysis methods by statistical evaluation of determined perfusion flow. The analysis methods investigated were Fermi function (1), Modelfree Deconvolution (2), Modified Tofts (3), Exchange (4), Uptake (5), Tofts (6), Patlak (7), and Maximum Slope (8).
منابع مشابه
Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: comparison to single-bolus injection method.
PURPOSE To compare the dual-bolus to single-bolus quantitative first-pass magnetic resonance myocardial perfusion imaging for estimation of absolute myocardial blood flow (MBF). MATERIALS AND METHODS Dogs had local hyperemia of MBF in the left anterior descending (LAD) coronary artery (intracoronary adenosine). Animals (n = 6) had sequential single- and dual-bolus perfusion studies with micro...
متن کاملQuantitative Myocardial Perfusion Using Conventional Single-Bolus Contrast Imaging Overestimates Absolute Myocardial Blood Flow Compared with Dual-Bolus or Dual-Sequence Cardiac MR Methods
Introduction: Estimates of myocardial blood flow (MBF) from first-pass contrast-enhanced cardiac magnetic resonance (CMR) imaging require accurate measurement of the arterial input function (AIF) from the left-ventricular (LV) blood pool. Both dual-bolus [1] and dual-sequence [2,3] CMR methods have been proposed to maintain the linearity of the LV signal during the contrast passage. Several stu...
متن کاملMeasurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: comparison of distributed parameter and Fermi models with single and dual bolus
BACKGROUND Mathematical modeling of cardiovascular magnetic resonance perfusion data allows absolute quantification of myocardial blood flow. Saturation of left ventricle signal during standard contrast administration can compromise the input function used when applying these models. This saturation effect is evident during application of standard Fermi models in single bolus perfusion data. Du...
متن کاملDevelopment of a universal dual-bolus injection scheme for the quantitative assessment of myocardial perfusion cardiovascular magnetic resonance
BACKGROUND The dual-bolus protocol enables accurate quantification of myocardial blood flow (MBF) by first-pass perfusion cardiovascular magnetic resonance (CMR). However, despite the advantages and increasing demand for the dual-bolus method for accurate quantification of MBF, thus far, it has not been widely used in the field of quantitative perfusion CMR. The main reasons for this are that t...
متن کاملOptimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps
BACKGROUND In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically. Dual-saturation acquisiti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 15 شماره
صفحات -
تاریخ انتشار 2013